Endoplasmic Reticulum Stress, Pancreatic -Cell Degeneration, and Diabetes
نویسندگان
چکیده
منابع مشابه
Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes.
Overwhelming of protein folding in the endoplasmic reticulum (ER)--referred to as "ER stress"--activates a set of intracellular signaling pathways termed the unfolded protein response (UPR). Beneficial outputs of the UPR promote adaptation in cells experiencing manageably low levels of ER stress. However, if ER stress reaches critically high levels, the UPR uses destructive outputs to trigger p...
متن کاملA Busy Cell – Endoplasmic Reticulum Stress in the Pancreatic -cell
HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau...
متن کاملEndoplasmic reticulum (ER) stress & diabetes.
The endoplasmic reticulum (ER) is a central organelle entrusted with lipid synthesis, protein folding and protein maturation. It is endowed with a quality control system that facilitates the recognition and targeting of aberrant proteins for degradation. When the capacity of this quality control system is exceeded, a stress response (ER stress) is switched on. Prolonged stress leads to apoptosi...
متن کاملEndoplasmic Reticulum Stress and Pancreatic Cancer
Endoplazmik retikulum (ER) stres, farklı uyaranlar sonucu gelişen önemli hücresel bir olaydır. ER strese farklı yanıt türleri vardır. Bunlardan biri evrimsel olarak korunmuş katlanmamış protein cevabıdır (UPR). UPR’nin moleküllerin sonraki aktivasyonu için üç sensörü vardır. Bu sensörler inozitol gerektiren enzim 1 (IRE1), aktive edici transkripsiyon faktörü 6 (ATF6) ve protein kinaz RNA (PKR)-...
متن کاملInvolvement of Endoplasmic Reticulum Stress in TULP1 Induced Retinal Degeneration
Inherited retinal disorders (IRDs) result in severe visual impairments in children and adults. A challenge in the field of retinal degenerations is identifying mechanisms of photoreceptor cell death related to specific genetic mutations. Mutations in the gene TULP1 have been associated with two forms of IRDs, early-onset retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA). TULP1 is a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Medicine
سال: 2012
ISSN: 2157-1422
DOI: 10.1101/cshperspect.a007666